Feb 17, 2023 12:22
1 yr ago
24 viewers *
English term
Spain
Native in: Spanish (Variant: Standard-Spain) 
Works in: Spanish to English, English to Spanish
positions (Kabat) and (EU),
English to Spanish
Law/Patents
Chemistry; Chem Sci/Eng
Me gustaría saber que significa ese "EU".
Tengo claro lo de posiciones "Kabat" pero ¿posiciones EU?
Gracias
Tengo claro lo de posiciones "Kabat" pero ¿posiciones EU?
Gracias
Proposed translations
(Spanish)
| 3 +1 | las posiciones (Kabat) y (Eu) |
Neil Ashby
|
Proposed translations
+1
41 mins
Neil Ashby
Spain
Spain
Native in English
Specializes in field
Spain
DrNeil TechTrans, Precision & Clarity
Native in: English
Works in: Spanish to English, English
Related KudoZ points
:
153
las posiciones (Kabat) y (Eu)
https://www.imgt.org/IMGTScientificChart/Numbering/Hu_IGHGnb...
They are just different amino acids numbering systems.
Correspondence between the IMGT unique numbering for C-DOMAIN, the IMGT exon numbering, the Eu and Kabat numberings: Human IGHG
The IMGT unique numbering for C-DOMAIN is used in the Protein displays.
Hinge amino acids are shown at the bottom of the page.
Amino acids resulting from the splicing are shown between parentheses.
Colors of amino acids are according to IMGT Color menu for sequence alignments."
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Note added at 41 mins (2023-02-17 13:04:29 GMT)
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Hi Celia. Please explain your (inevitable) disagreement.
They are just different amino acids numbering systems.
Correspondence between the IMGT unique numbering for C-DOMAIN, the IMGT exon numbering, the Eu and Kabat numberings: Human IGHG
The IMGT unique numbering for C-DOMAIN is used in the Protein displays.
Hinge amino acids are shown at the bottom of the page.
Amino acids resulting from the splicing are shown between parentheses.
Colors of amino acids are according to IMGT Color menu for sequence alignments."
--------------------------------------------------
Note added at 41 mins (2023-02-17 13:04:29 GMT)
--------------------------------------------------
Hi Celia. Please explain your (inevitable) disagreement.
Discussion
"In certain embodiments, a heterodimeric antibody of the invention comprises a first heavy chain and a second heavy chain and a first light chain and a second light chain, wherein the first heavy chain comprises amino acid substitutions at positions 44 (Kabat), 183 (EU), 392 (EU) and 409 (EU), wherein the second heavy chain comprises amino acid substitutions at positions 44 (Kabat), 183 (EU), 356 (EU) and 399 (EU), wherein the first and second light chains comprise an amino acid substitution at positions 100 (Kabat) and 176 (EU), and wherein the amino acid substitutions introduce a charged amino acid at said positions"